2009/05/31

Dopamine neurons don't just encode valence -- Some encode salience

Two types of dopamine neuron distinctly convey positive and negative motivational signals

Nature advance online publication 17 May 2009.

Masayuki Matsumoto & Okihide Hikosaka


This is the classical kind of (putative) DA neurons, which show opposite responses to reward and punishment, thus encoding the valence of a stimulus.

This classical picture is well and good. But not so fast...









Mastumoto and Hikosaka here show that there is in fact another group of (putative) DA neurons, which have similar bursting responses to both reward and punishment. Thus, it appears that these DA neurons are encoding the salience of a stimulus, reminiscent of how basal forebrain neurons encode salience.









6 comments:

burakerdeniz said...

Hi there, thank you for your nice blog. I enjoyed reading your posts.
BG codes salience or valence or both or learning or motor or value and most probably all. This looks like a very complicate story.

Here is the link from another paper
Berridge, K.C. 'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders. Physiology & Behavior, 2009.

Anonymous said...

Are there any awards like this for using neuroplasticity for large scale health interventions?

I have been following Emotional Brain Training for a while.

http://ebtnews.blogspot.com/

They seem to be pretty exciting in turing some of these ideas into large scale impacts on society.

123 123 said...

Nice article as for me. I'd like to read more concerning this matter. Thnx for sharing that info.
Joan Stepsen
Wise geek

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Jack Gugel said...

Awesome blog. This stuff is great.

Dave said...

This is a great analysis and illustration about dopamine neurons. This neuro blog really shares valuable information. It is the reason why I love visiting your blog.